Q: Should I use Hyper-V Replica with Exchange servers?

A: If you're considering whether to use Hyper-V Replica with Exchange, just remember that Exchange has its own disaster recovery and site awareness capabilities that should be used instead. Hyper-V Replica isn't needed and isn't supported because of problems with Exchange's roles being forced back in time in the event of an unplanned failover. More information can be found at "Microsoft Support Policies and Recommendations for Exchange Servers in Hardware Virtualization Environments"  and "Understanding Exchange Virtualization" around technologies supported by Exchange.