Storage Spaces Direct across locations?

Q. Can I use Storage Spaces Direct across locations?

A. No. Storage Spaces Direct aggregates local storage on cluster nodes to provide resilient clustered storage via SMB 3 but requires very low latencies between the nodes as replication is synchronous. This synchronous replication makes using S2D across locations impractical and a S2D cluster cannot be stretched across locations. A better solution would be to create two separate S2D instances, one in each location, then use Storage Replica to replicate the content from one instance to the other!