Q. I'm using Microsoft Application Virtualization (App-V) with AppLocker and none of my virtualized applications will launch. Why not?

Start the Group Policy Management Editor and edit a group policy object that will host the AppLocker new exception.

Navigate to Computer Configuration, Policies, Windows Settings, Security Settings, Application Control Policies, AppLocker, Executable Rules.

Run the Create New Rule action and click Next.

Specify the users to whom the rule will apply. By default, this is Everyone.

For Conditions, select Path and click Next.

For the Path, select q:* and click Next.

Leave the Exceptions page blank and click Next.

Give the rule a name, such as App-V Applications (q:*), and click Create.

Make sure the group policy object is linked to the computers that run the App-V applications.